Subgroup analyses of trials achieving ⩾80 nmol/l indicated a trend for lower CRP (WMD=−0.834, (−1.726, 0.058) mg/l, P=0.067), however heterogeneity was significant ( I 2=66.7%, P=0.017). Of 14 studies that met our criteria, 9 studies (15 study arms) permitted extraction of data. Selected RCTs were ⩾12 weeks, conducted in adults free of acute inflammatory disease, and of high-quality (Jadad score ⩾3). Causal links between vitamin D status and systemic inflammation were examined through a systematic review of randomized controlled trials (RCTs).
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